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Coadministration of pexidartinib (a CYP3A4 inducer) with sensitive CYP3A substrates might produce really serious therapeutic failures. If concomitant use is unavoidable, raise the CYP3A substrate dosage in accordance with permitted solution labeling.primidone will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4

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